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Rumination 21 Experimental Design 101

Thursday, 5 March 2009

Rumination 19 Waiting for Godot

Saturday, 13 December 2008

Rumination 17. Dear Diary

Sunday, 5 October 2008

Rumination 16: Bad News, Good News

Wednesday, 10 September 2008

Ruminations 15: Lawyers 10, Science 1

Tuesday, 5 August 2008

Rumination 14

Monday, 7 July 2008

Rumination 13 - This is Science?

Saturday, 10 May 2008

Rumination 12 - Stable is Good

Wednesday, 19 March 2008

Ruminations collected

Thursday, 3 January 2008

Ruminations 10: Not So Glad Tidings

Sunday, 16 December 2007

Rumination 9. An Experiment in Diagnostics

Friday, 21 September 2007

Rumination 8: Whodathunkit!

Saturday, 4 August 2007

Rumination 7: The Path Ahead

Sunday, 24 June 2007

Rumination 6: Intermission

Saturday, 26 May 2007

Rumination 5 - The Lost Month

Monday, 14 May 2007

Ruminations 3

Thursday, 22 March 2007

Ruminations 2 - Reprieve

Friday, 9 March 2007

Rumination 1 - Reprise

Monday, 5 February 2007

Latest Entries

Rumination 22: If at First You Don't Succeed

Friday, 1 May 2009 1:20 P GMT-05
Rumination 22. If at First You Don't Succeed
By
Thomas P. Vogl
May 1, 2009


I have now been on my new drug, AUY922, an Hsp90 inhibitor by Novartis, for almost eight weeks of weekly infusions. A CT scan last week showed that I was stable (no progression of disease) and that there were hints that the vascularization (blood vessels) at the periphery of the tumors was decreasing. However, a PET scan a week later showed that the many liver metastases were continuing their slow growth and some lab measures of liver function are deteriorating. I hasten to add that my liver is not enlarged and that I continue to be asymptomatic.

So, yesterday, after a lengthy and most helpful consultations with Drs. Geoffrey Shapiro, Bruno Bastos and Andrew Wolanski, with a telephone consult with Dr. Frank Hodi thrown in for good measure, we decided to take me off the AUY922 trial. Since any new trial would have to wait a month wash-out period before I could be started on it, and there was no Phase I trial that seemed obviously appropriate, the collective decision was a trial of Sutent (www.sutent.com/), an FDA approved drug for renal cell carcinoma and gastrointestinal stroma tumors, and thus immediately available by prescription rather than through a study. Its use for melanoma would be off label (not a big deal - done all the time) and there have been recent reports that it is effective in 20% of uveal melanoma patients, which for anti-cancer drugs is a huge success rate. Scans in eight weeks will see whether it is working. One of the major fringe benefits of the new regimen is that I have to go to Boston only once a month for a checkup and can monitor my own blood pressure and have labs drawn locally. Hurray! Only time will tell how well I tolerate Sutent and whether it works on me.

So, at this point I am off any Phase I trial and therefore no longer being treated in DFCI's CRC (Clinical Research Center). I cannot part from the CRC without expressing my thanks and profound admiration for the entire staff of the CRC, singling out DeeDee (Demetra) McDonald, Susan Coggeshall-Aikey, Moira Pevear, and Caroline Charron because they were responsible for my care and worked such wonders to make a difficult time much easier.

The AUY922 study design, particularly the first five weeks, is very hard on the patient. In those five weeks I spent three long weekends (Thursday afternoon through Monday morning) in Boston. Starting early in the morning on Friday (which is why I had to arrive Thursday afternoon) eight hours of hourly EKGs, each in triplicate, as well as a bizarre schedule of blood draws that had three hour intervals followed by one hour intervals. The rest of the weekend I had to go in for just 30 minutes each mornings for the EKGs and a blood draw. The blood draw was to measure drug levels and therefore could not be done locally. What really galled was that the four day weekend rigmarole was required with the fourth (last) infusion of the first cycle and, a week later, with the first infusion of the second cycle - as if anything will change between the fourth and fifth infusion a week apart! Thereafter I could have gone to Boston once a week in the morning and come back that afternoon except once every eight weeks for scans. No getting around it, March was hard on both of us and we are just now recovered.

No drug is without side effects and AUY922 is no exception. These new small molecule anti-cancer drugs, just like the older drugs, work on relatively small differences between normal and malignant cells, usually differences in speed of reproduction. That is why so many anti-cancer drugs have side effects such as hair loss (hair grows quickly), gastrointestinal problems (the lining of the intestine reproduces rapidly) etc. Which is why I now have only one third of the hair I had two years ago.

Hsp90 is one of a class of chaperone proteins, whose normal job is to help other proteins acquire and maintain the shape required for those proteins to do their jobs. Chaperone proteins work by being in physical contact with other proteins. Hsp90 can also enable cancer cells to survive and even thrive despite genetic defects which would normally cause such cells to die. Thus, blocking the function of HSP90 and related chaperone proteins may cause cancer cells to die. Of course, treating with a combination of drugs acting differently toward the same end is more effective that a single drug but that research is not supported because it is not in the interest of a drug company seeking a blockbuster for their own drug.

Some of the side effects of AUY922 (and probably other drugs with HSp90 as the target) are, at least to me, fascinating. Probably not as fascinating to you, dear reader, than to me and a subset of the scientific community. So I will deal with it below the break. Suffice it to say that they are annoying but tolerable by my definition of not interfering excessively with my normal activities.

********************************************************************************************************

Hsp90 is ubiquitous in the body and comprises 1-2% of total proteins in most tissues under non-stress conditions. To oversimplify, its function is to regulate protein folding, since misfolded proteins cannot execute their intended function. Tumor cells have an extraordinary reliance on Hsp90 which complrises as much as 4-6% of total proteins in tumor cells [L. Yanyan et al., New developments in Hsp90 inhibitors as anti-cancer therapeutics: clinical perspective and more potential. Drug Resistance Updates, 12 (1-2): 17-27 (February-April 2009)]. Thus Hsp90 inhibitor, like so many other old and new anti-cancer drugs, relies on relatively subtle differences between normal and cancer cells for its effectiveness. It is, therefore, not surprising that side effects abound; rather, it is surprising that for these new drugs they are so few and relatively mild.

One of the known (among many unknown) clients of Hsp90 is rhodopsin, one of the five photosensitive 'opsins' in the eye. Rhodopsin is the active pigment in the rod cells of the retina that are responsible for night vision. Three other opsins are responsible for color vision in the cone cells. The fifth opsin is melanopsin, which serves to control the size of the pupil in response to light as well as providing a signal to the pituitary gland to help regulate circadian rhythms.

To summarize my symptoms, they are (1) markedly reduced night vision, particularly on days 1 and 2 (the day of the infusion is day 0) that recovers substantially by day 4; (2) A marked decrease in my ability to adapt to changes in illumination level, particularly noticeable when going from well lit to poorly lit areas, as evidenced by my perception that areas that I used to consider adequately lit now appear quite dark (particularly when I come in from a well lit area); that Katherine observes that under these condition my pupils are 'tiny'; the effect diminishes far more slowly than (1); and (3) when I first wake up in the early dawn light, both the off-white (in the direction of orange) wall in our bedroom as well as the cloudy sky have a distinct green cast.

Effect (1) can be explained by the known rhodopsin requirement for Hsp90; (2) could be explained by a similar, yet undocumented, requirement of melanopsin for Hsp90; a possible relationship is that both of these opsins are Vitamin A derivatives; (3) still lacks a cogent explanation - under photopic (day-time) conditions I have never observed any derangements of color balance. It is difficult to imagine that AUY922 acts so uniformly across three different opsins that the color balance remains unaffected and if the effect were due to such a derangement it would not vanish promptly as soon as photopic vision is restored. It is noteworthy, but not explanatory, that the peak in spectral sensitivity of rhodopsin is in the yellow-green, just about the color I observe.


The collected Ruminations may be found at http://upislandeggs.com/Ruminations.htm
and my e-mail addresses at the bottom of the page at http://upislandeggs.com/

Rumination 21 Experimental Design 101

Thursday, 5 March 2009 8:14 A GMT-05
                      Rumination 21. Experimental design 101
                                                         By
                                           Thomas P. Vogl
                                             March 5, 2009

I have just spent a week in Boston, arriving late Tuesday 2/25 and finally getting home on Tuesday, 3/3 because the Nor'easter on Monday canceled both buses and planes (I spent six hours at the airport after which Cape Air canceled the delayed flight.) Wednesday and Thursday were devoted to scans - ECHO cardiogram, CT scan, and two PET scans, one with FDG and the other with FLT. The FDG is the usual pet scan using glucose with a radioactive tagged fluorine atom attached; the FLT is a fluorothymidine with a tagged fluorine atom that identifies high thymidine kinase-1 activity. FDG allows visualization of glucose metabolism which indicates how active the cell is; FLT allows visualization of DNA turnover, a measure of cell division (proliferation). If you think of cells as rabbits, FDG PET tells you how much they are running around and FLT PET tells you how fast they are breeding. FDG PET is a recognized and approved procedure; FLT is still experimental and it looks like it is more useful for blood cancers, such as the lymphomas, than for solid tumors like carcinomas, melanomas, etc. On Friday I had the first infusion of the new drug, AUY922, an Hsp90 inhibitor and endless hourly EKGs, (I suspect the plethora of EKGs are the contribution of the lawyers who may have had more input into the experimental design than the scientists.) The only side effect was a tolerable level of diarrhea.

The scans showed that in the five weeks since my previous scan the size of my metastases had increased only slightly despite the fact that there had been no treatment during that time and that the treatment in the previous three to six weeks had been ineffective. Looking back over my shoulder at the whole sequence of events since my initial surgery in July of 2005, it is clear that my mucosal melanoma is exceptionally indolent considering that mucosal melanoma is known to be especially aggressive and fast growing, even compared to dermal melanoma. Now, whether this is due to particular strengths in my immune system, or a genetic peculiarity of my melanoma, or the effect of some combination of the Celebrex and fish and flax oils, all of which actively reduce inflammation, is not known and cannot be determined. However, I'll take what I can get. The reason it cannot be determined is relevant to the primary topic of this rumination.

An obvious experiment would be for me to stop taking the Celebrex and fish/flax oils for four to six weeks and see if the disease progress has increased; then, as a check, resume the three 'drugs' (technically the oils are not drugs) and see if the progression again slows down. What is wrong with this scenario? There are three possible outcomes: (1) progression increases when the drugs are withdrawn and decreases when they are resumed; (2) progression increases when the drugs are withdrawn and continues to increase when they are resumed; (3) progression does not change throughout. In case 1, the conclusion that the drugs are of benefit is reasonable; in case 3, the conclusion that the drug is of no benefit is reasonable; but in case 2 the conclusion that the drug is of no benefit is not reasonable because the increase while the drugs were withdrawn may have overwhelmed the immune system and that the drugs, while effective before, are no longer up to the task. So, in that case, we have learned nothing. Consequently, it is a poorly designed experiment because it is a fundamental principle of experimental design that a well designed experiment yields useful information irrespective of the outcome of the experiment. It is a dictum as fundamental to experimental design as 'Above all do no harm' is to medicine.

So, in that spirit, let us examine the design of clinical trials. To make the discussion concrete, consider an (imaginary) drug, TPV001, that in animal experiments has been shown to produce an effective treatment (of some disease) at a dose of 60 U(nits).

The first step is to clearly state the objectives of the experiment. I submit that the appropriate objective is 'Is this drug effective in humans without producing unacceptable side effects'. Put more formally, can we disprove the statement (null hypothesis) that TPV001 is ineffective or that it causes unacceptable side effects. Let us further suppose that we can afford to test the drug on 40 individuals and that this is a sufficient number to satisfy the statistical requirements.

What the drug companies have elected to do is to divorce the primary objective (does it work) from the secondary objective (and can it do so without unacceptable side effects) and give primacy to the secondary objective. In fact, they ignore the primary objective until they have established whether the secondary objective can be met. This is called a phase I dose escalation trial. So, they take their 40 patients and give the drug to the first 10 patients at a dose of 15U. These patients exhibit no side effects and no therapeutic benefit. What has been learned from this experiment? Essentially nothing -- no side effects (that's nice), no therapeutic benefit (not a surprise at this dose). If the drug companies were honest with these patients they would have told them from the beginning that the chance of this dose doing them any good at all was minimal.

The next group of 10 patients get 30 U. Of the 10, two have mild side effects, say one has fatigue lasting less than 48 hours and the other mild diarrhea lasting less than a day. One of these patients showed a slight therapeutic benefit. What does this experiment show? Not much. It suggests that the drug may work on people and that at this dosage the side effects are mild and the therapeutic effect, milder.

The next group of 10 get 45 U. Four have mild side effects, one had more severe but still acceptable side effects, and one has severe enough side effects to cause concern. Three patients demonstrate some therapeutic benefit, say lack of progression. While some information can be gleaned from knowing whether it is the patients who had the side effects were the ones who benefited from the treatment, the most likely (and usual) result is that some of the patients who benefited had no side effects.

Undaunted, because the FDA has approved the protocol and it is, therefore, set in concrete, they forge ahead to a dose of 60U for the last group of 10 patients. Now there are 4 severe and 4 moderate side effects and some therapeutic response in 6 patients. They conclude that four severe reactions is too much and go on to the phase II trial (therapeutic efficacy) at 45 U.

At 45 U, the phase II trial fails to show adequate efficacy in a sufficient number of patients and the drug is abandoned. This is the fate of about 80% or more of the drugs entering phase I trials. What an incredible waste of time and money. All that has really been shown is the well known fact that people differ greatly in response to drugs and that the average response of a group of ten patients totally fails to capture the extent of the variation.

With the same number of subject, there is a much better way, i.e., a way that yields far more information without any added danger to the patients. In fact, when compared to the current system, it diminishes the danger to the most at risk group (the last ten subjects) and an enhances the likelihood of benefits to the group least likely to benefit under the current system (the first ten subjects).

As before, start the first ten patients at 15U. If they show no adverse reaction, escalate the dose to 30U for each of those patients, Continue the dose escalation on each patient until the criteria used before to establish the unacceptability of side effects is reached, but on each patient individually. Note that this does not subject any patient to more risk that they would be exposed to if they had been part of the 40 patient group described above (much less risk for the last 10). But it has huge advantages: It immediately relates the dose, side effects,and therapeutic efficacy for each individual patient; it assures each patient that if there is therapeutic potential for him/her, then it will be reached; and it allows an immediate initial quantitative determination of not only the average maximum tolerable dose (MTD) but also of its variance.

Assume that from this first group of 10, it is determined that the MTD is 42 +/- 16 U. Then the next group of 10 patients can be started at, say, 41-16 (1 SD below the mean) at 26 U and the dose escalation might be in 10U steps instead of 15U steps as it was in the first group.

By the time all four groups of 10 have been through this study, so much more will be known: the MTD for all 40 subjects individually and its variance; the therapeutic response of each of the 40 to their individualized MTD; the side effects of each individual at their MTD and whether it is correlated with therapeutic efficacy, and even dose-response curves. Last, but not least, each of the 40 patients will have had the same optimal opportunity to benefit from the trial. Little, if any, of such data are available from Phase I studies as currently carried out.

The pharmaceutical companies are not incompetent and they have highly skilled scientists and statisticians in their employ. The same can be said about the FDA, possibly not quite as enthusiastically. Consequently, I find it difficult to believe that the current system is the result of negligence or stupidity. That leaves the question of how the current state of affairs came about and why it continues. It is a mystery. As the detectives would have it, cui bono? I cannot figure it out. Maybe a reader can enlighten me. I will appreciate it.

The collected Ruminations may be found at http://upislandeggs.com/Ruminations.htm
and my e-mail address at the bottom of the page at http://upislandeggs.com/

tags:    

With the second half of the croissant dough

Thursday, 26 February 2009 10:33 A GMT-05
I'm stuffing the croissant dough this time. The experiments have either white chocolate or Tom's very dense Oxford-style marmalade or leftover gremolata (a parsley, minced lemon peel and minced garlic mix). And the scraps will be bread sticks dusted with my Parm. We will see!

Category: Hungry?

Facebook, Croissants, Spring

Saturday, 21 February 2009 10:21 A GMT-05

Tom and I have stuck our toes in the waters of Facebook - so you can "friend" us if you like. Most of his family and some of mine are already on it and I've reconnected with several old friends from high school and college.

The latest small bread project has been real croissants.

This is the third try, and though the first two were edible, these are pretty close to the way they should be. I used the recipe from the King Arthur Flour Baker's Companion and the only thing I did differently was to use a cultured unsalted butter. I bought a new, huge rolling pin for the recipe and it worked beautifully.

I've been debating about whether a big pastry board is worth the cost in both terms of money and storage space. The croissants are rolled out into a big rectangle and only one countertop in the kitchen - which usually has the plastic wrap holder, thermo sealer and electric grill on it - is big enough. Fantes has a wooden one I've been eyeing,  28" X 22.5", and a silicone one as well, though I sent the small silicone pastry mat I had to the Dumptique because everything stuck to it. I suspect I'll stick with the counter, though Tom thinks I ought to ask the guys at Krug & Ryan who made our lovely cutting board to make one for us.

The chickens are doing fine and laying tons of eggs. The zebra finches are having a batch of babies every week or so. We have no idea how many zeebs are in the sunroom, but they don't look crowded. They are, however, eating vast quantities of finch food which has become very hard to get on island, at least in big sacks. Either the feed store doesn't have a big enough order to put in with the bird food company, or, when they do order, the company is backordered on the food we need. Kaytee Forti-Diet Finch food is their favorite, but they will eat whatever finch food we can find!

Spring is here - Tom needs to show me some plumbing stuff in case the flapper valve on the toilet breaks while he is in Boston for a week for his new treatment (he leaves Tuesday afternoon.) 

 

Rumination 20. Clinical Trials and Tribulations

Sunday, 15 February 2009 11:05 A GMT-05

Rumination 20. Clinical Trials and Tribulations

                                          By
                                               Thomas P. Vogl
                                               February 15, 2009

The inanities and insanities of clinical trial protocols have caught up with me with a vengeance. I started the trial of the Cdk inhibitor SCH727965 in September at what at that time had been determined to be the maximum tolerable dose and I had a fairly severe immediate reaction to the drug - my blood pressure dropped and I went into the classic definition of shock which a rapid infusion of fluids quickly and easily corrected. Consequently the powers that be (i.e., the drug company) decided that the next time, three weeks later, I was to receive only half the dose. I also was given much earlier and more aggressive fluid support. At that dose and with the fluid support I experienced only the mildest of the expected side effects. Three weeks later, my regularly scheduled scans showed a noticeable drug effect on my tumors and the lower dose infusion the next day caused only the slightest sign of any side effects. The next treatment, three weeks later at the same lower dose had no side effects at all. My body clearly was getting used to the drug. I discussed increasing the dose with adequate fluid support and was told that once the dose had been reduced increasing it again was not permitted. The next set of scans (every six weeks) showed stable disease but no drug effect. Six weeks later (in January) my tumors had progressed and I was kicked off the study.

I have since learned that the established dose has been decreased further and indeed no side effects have been reported on this new dose. Of course, no success has been reported either. Administration of all drugs, and particularly new drugs, need to take into account something that all practicing physicians know (but too often ignore), namely that an individual's response to many drugs varies greatly. It makes little or no sense to try to determine maximum tolerated dose (MTD) on groups of patients where if even a small number of patients have serious side effects, everyone's dose is lowered. Dose escalation must be done on individual patients to be meaningful: Somewhere around 75% of the averaged MTD determined individually on the first group of patients is probably a good place to start dose escalation for the next group of patients. The low end MTD of the group is not necessarily, or even often, close to the optimal dose for the majority of patients. The Cdk inhibitor was showing every sign of working on me, but the drug company with the connivance of the FDA had my physician's hands tied and the lower dose, not surprisingly, had no effect. Is it any wonder that 80 - 90% of all clinical trials of new drugs fail? I have a suspicion that it is the lawyers (if anything goes awry we'll find someone whose fault it is, and, oh boy, will we make them pay) that bear the brunt of the blame, but the courts also bear responsibility for allowing the current state of affairs to develop and continue.

There is an interesting sidelight to all this. Drug companies love to complain about the cost of clinical trials and use this cost as an excuse to jack up the price of the few drugs that make it through the clinical trial process. Just consider how much money they would save if clinical trials focused on the clinical instead of the trial and considered therapeutic response from the very beginning. Furthermore, what seems never to be mentioned is that they bear only a small part of the cost. Much of the cost of the administration of the drug and the care of the patient during the clinical trial is passed on to Medicare and other insurance carriers, irrespective of the absurdity of the protocol, once the protocol has been rubber stamped by the FDA. "When will they ever learn, when ..."

None the less, unless I throw in the towel, I need to find a new study in which to participate. So, on February 11, I met with Dr. Shapiro in the morning and Dr. Hodi after lunch. Details of the considerations are discussed below the break. The upshot was unanimous agreement that an Hsp90 inhibitor was first choice of the way to go. (I have complained vociferously in the past about my interactions with Dr. Hodi. While I do not retroactively withdraw those complaints, I must report that what was true then is most certainly not true today. Our interaction was professional, most pleasant, highly instructive, and a much appreciated change from earlier days; I relish his highly knowledgeable input, positive tone, and offers of help.)

We all agreed that three classes of drugs were the most likely to be of benefit to me. Of these, the Hsp90 inhibitors were the most attractive for both theoretical and practical reasons. The theoretical reasons is that Hsp90 is a component of several of the relevant cellular signaling pathways. The practical reason is that no slots were available in the other trials for several months. Of the ongoing Hsp90 trials only two were practical for me in terms of travel and stay requirements. One is being run by NCI (National Cancer Institute, NIH) in Bethesda but would probably require relatively infrequent visits (it is an orally administered drug but I have not explored the details) and the other by Dr. Shapiro at DFCI that will require weekly visits for infusion. Because I have such high professional and personal regard for Dr. Shapiro and everyone on the staff of his unit, I asked to be considered for that Hsp90 trial, a Novartis drug, AUY922. I heard on Thursday (2/12) that Novartis has accepted me into the trial. I expect that the preliminaries, scans, EKG, etc., will happen next week. I note in passing how quickly things are changing in cancer therapeutics. Six months ago the consensus was that CTLA-4 inhibitors were the way to go and the Hsp90 inhibitors were speculative at best. I can't wait to find out what the drug of choice will be six months hence when Hsp90's stop working on me.

This is also the appropriate moment to talk about the genome sequencing on a sample of tissue removed from a metastatic lymph node in my neck, that was organized by my friends an N-of-One (http://www.n-of-one.com/), Drs. June Kinoshita and Jennifer Carter. The results are indicative of the current state of individualized genomic medicine. The analysis identified only mutations. Most of the mutations identified in my tumor code proteins with unknown function. Many cancer-related genomic changes are replications, not mutations, and the study that was done did not identify them. That is not to say that the study was not marginally useful. It allowed us to decide that Gleevec, a drug useful for c-KIT mutations but not replications would not help me. It also suggested that the available MET inhibitors, PF02341066, would probably not be useful in my case. (The results for the sample sent out for sequencing are not back.) So, while not as useful as such sequencing will be in the years to come, it was useful in reducing the field of choices for the next drug to try.

**************************************************************************************

I will go into some detail of my choice for the next trial, because it contains a cautionary tale of general applicability. It also demonstrates how very quickly the field of cancer drugs is moving.

Before my meetings on the 11th, I compiled a list of studies worthy of consideration. the list was

PF-02341066 C-MET/Selective Tyrosine kinase inhibitor.
Pfizer @ DFCI. NCT00585195
G. Shapiro, MD
My MET currently being sequenced to evaluate eligibility.

ENMD 2076 anti Aurora A / anti angiogenic kinases (VEGFr)
EntreMed @ DFCI NCT00658671
G. Shapiro MD
 
MDX 1106 Anti-PD1 human monoclonal antibody
Medarex @ Yale.  NCT00730639
Mario Sznol, MD 203-785-2604

Melphalan - liver infusion & recapture (Phase III)
NCI @ NCI NCT00324727
NCI 888-NCI-1937
 
CTLA-4/Avastin (Ipilimumab/Bevacizumab)
Genentec, B-MS @ DFCI NCT00790010
Hodi
 
SUO 11248 / Sutent / sunitinib Oral Tyrosine-kinase inhibitor / anti c-KIT
Pfizer @ DFCI NCT00577382
F. S. Hodi, MD 617-632-5053
 
Imatinib / Gleevec Anti Bcr-Abl Protein tyrosine kinase
Novartic @ DFCI NCT00424515
Hodi
Qestion: Is my c-KIT mutation or replication?
 
SNX 5422 Oral Mesylate Hsp90 inhibitor
Pfizer @ NCI. NCT00647764
Pfizer 877-369-9753

 I also identified three studies about which I knew too little to do other that to ask about then:

MCDG 265 (same as/similar to?) XL 184. Anti-(RET)RTK, MET, VEGFr-2
@ Chicago & DFCI Shapiro?
 
PX 866 / BEZ 235. P13K Inhibitor
Novartis @ Nashville NCT 00620594
Howard Burris, MD 615-329-7224
 
HGS1029 (AEG40826) IAP inhibitor
Human Genome Sciences @ Nashville NCT00708006
Dan Oderheimer Ph.D. 866-447-9749

When I started my search, I thought that the CTLA-4 inhibitor with the unpronounceable name of Ipilumimab (Ipi) would be my first choice, because the two people I know who also have metastatic melanoma were on this drug and both had excellent long-term results with very few, if any, side effects. I did know that previous studies have demonstrated that no more than 8-12% of patients on Ipi received any benefit. What I did not know until I searched the recent literature [J. Weber, Overcoming Immunologic Tolerance to Melanoma: Targeting CTLA-4 with Ipilumimab (MDX-010). The oncologist 2008:13 (suppl. 4):16-25; and G. Q. Phan et al, CTLA-4 Blockade with Monoclonal Antibodies Metastatic Cancer: Surgical Issues. Annals of Surgical Oncology 15:3014-21 (2008)] was how frequent and serious long term side effects are with this drug. It turns out that benefit is usually attained only in patients who also have significant side effects. So, much to my surprise, that drug went from the top to near the bottom of my list. The cautionary moral of this story is how knowing a few patients can so mislead one from the realities of evidence based medicine.

Of course, what drug one chooses when there is neither a clear choice nor a clear promise of benefit, must perforce be based on a personal cost/benefit analysis. My cost/benefit analysis is based on my firm conviction that at my age quality of life is the overriding consideration; quantity counts for very little. Based on that premise, I reject any drugs with only short duration of benefit, if any, (which includes all approved drugs for melanoma) and that have the possibility of producing long-lasting (more than a few days) side effects. That eliminates both Ipi and Sutent because of their frequent serious, long-lasting, side effects. The Aurora A inhibitor is high on the list of possibilities because my prior good experience with an Aurora-B inhibitor (AZD-1152) that kept me stable for several months and had no appreciable side effects. The addition of a VEGFr inhibitor (to inhibit angiogenesis) to an Aurora-A inhibitor is a very interesting and desirable attribute of that study. Unfortunately, no slots for the study will be available for several months.

Melphalan infusion and recapture has the advantage of addressing my liver metastases directly, and those are the only metastases I have that are life threatening in the immediate future. However, this study, now phase III (NCT00324727) [J. F. Pingpank et al., Phase I Study of Hepatic Arterial Melphalan Infusion and Hepatic Venous Hemofiltration Using Percutaneously Placed Catheters in patients with Unresectable Hepatic Malignancies. J. Clinical oncol. 23: 3465-74 (2005); B van Etten et al., Isolated Hepatic Perfusion with Melphalan in Patients with Irresectable Ocular melanoma Metastases. Eur. J. Surg. Oncol. (2008) doi:10.1016/j.ejso.2008.07.004] involves monthly general anesthesia and multiple catheter placement, so I think it is best reserved for consideration at some future time when I become symptomatic, and hopefully, the results of the currently ongoing trial of this approach become available.

What makes an Hsp90 inhibitor so attractive is that Hsp90 is essential for the MET, KIT, and VEGF pathways, all of which are known to be involved in the proliferation of melanoma.

(http://www.novartisoncology.com/research-innovation/pipeline/AUY922.jsp?usertrack.filter_applied=true&NovaId=7852773814828258984 ). Currently there are several Hsp90 inhibitors in clinical trials. Of these, at least two are impractical for me because they are administered so frequently that I would have to move to Boston. Two studies of Hsp90 appear to be practical. The SNX-5422 at NCI in Bethesda (now there is a commute) which is an oral preparation and a study of AUY922 with Dr. Shapiro at DFCI that, after the first five weeks (one infusion per week), can be done as a day trip. (The first five weeks will require ancillary tests - lots of EKGs that will require overnight stays). So, AUY922 is going to be the next step. stay tuned.


(Previous chapters of my Ruminations can be found at http://upislandeggs.com/Ruminations.htm )

Send in the Scones!

Saturday, 10 January 2009 6:21 P GMT-05
I've gotten drop biscuits, cut-out biscuits and English muffins figured out. Now on to scones! My first try was of the Cook's Illustrated version of oatmeal scones. I think they will need a bit of practice and maybe combining with the King Arthur version .  Send me your scone recipes! And savory scones are sounding wonderful!

Tom's Bread Recipe - Revisited and Not No-Knead

Wednesday, 7 January 2009 9:25 A GMT-05

Tom was asked for his latest bread recipe - the one that started out as the New York Time's No-Knead Bread . And here is his reply:

Unfortunately, a simple question has a complicated answer.  The reason for this is that I have merged King Arthur's sourdough bread recipe with the handling/baking technique of the original no-knead bread as modified by some suggestions in Cook's Illustrated . Consequently, it is no longer no-knead. However, everyone thinks the results are so good that it is worth the effort.

1 cup (9 oz) "fed" sourdough starter (i.e., fed the day before)
1 1/2 cups (12 oz) lukewarm water (I use whey from Katherine's cheese making. You can also use milk, eggs, beer, etc., but each choice will produce a very different bread.)
5-6 cups (21 - 26 oz) high gluten bread flour (e.g., King Arthur Sir Lancelot . You can also use up to 20% rye flour or 40% whole wheat bread flour - again with very different results.)
1 Tbsp salt
1 Tbsp sugar (I use 2 Tbsp dried malt extract - from a beer making supply house)
 
Mix the starter with the liquid and then add 3 cups (4.25 oz flour/cup) flour. Stir well. It should be a moist, gloppy mess. Let rise at room temperature for a couple of hours and then in a cooler location overnight. (55-60F is ideal, but it is not fussy.)
 
The next morning, stir in the salt, sugar, and 2 cups of flour. The consistency will vary depending on how wet the starter was. Is not to worry. When the dough has roughly come together, knead the dough by machine or by hand until it is silky (5-8 minutes by machine, up to 15 minutes by hand). The dough should be tacky but not sticky which you adjust by adding more flour as needed. Until you get the feel of it, err on the moist side.
 
Cut four strips of parchment paper about 24" x 8" and fold them in half the long way, to give you 4 24" x 4" strips.  Spray the inside of the bowl in which the bread is to rise (the bowl should be roughly the same diameter at the cast iron Dutch oven in which you will be baking the bread) with Baker's Joy (a flour and oil mixture).  Place two of the strips in the bowl at right angles to each other. Place the other two strips, also at right angles to each other at a 45 degree rotation to fill in the gaps between the first two strips. There must be enough overhang of the strips so that you can grasp all the strips later. Spray the interior with Baker's Joy. Form the dough into a round loaf and put into the middle of the prepared bowl. If your house is dry, spray the top of the dough with a light coating of baker's Joy.
 
Let the bread rise until more than doubled in bulk, usually 2-4 hours depending on the temperature. Meanwhile, preheat the Dutch oven in the over to at least 400F, 425F is better. When the oven is hot and the bread has risen, quickly remove the lid of the Dutch oven, grasp all the tails of the parchment paper strips and lower the dough into the Dutch oven, leaving the paper in place. Put the lid on the Dutch oven in such a way that the tails are hanging out. Bake for 30 minutes, then remove the lid and bake for 12 - 15 minutes more to the desired degree of brownness.
 
Turn the bread out onto a cooling rack and remove the now darkened parchment paper.
 
Enjoy!
 
P.S. You can get Baker's Joy in any supermarket. If you want some sourdough starter, we'll give you some if you are close by, or ours originally came from King Arthur .

Category: Hungry?

Bye 2008! Hi 2009!

Tuesday, 6 January 2009 1:08 P GMT-05

Bye 2008! Hi 2009!



2008 was amazingly good to and for both of us. Tom is stable and feeling fine, the chickens are doing well, Katherine has learned to knit cables, and the island is wonderful.

Tom spent a good deal of time going to Boston for treatments, though that has calmed down to once every three weeks. (You can find all the details about his medical journey as they happen in his Ruminations on this blog or the collected version on our web site upislandeggs.com/Ruminations.htm


We borrowed broody hens and let them hatch out eggs for us. Out of that batch came a truly amazing rooster who battles the crows who swoop down trying to grab the chicken treat. Our suspicion to one of the tricks to having a well-behaved non-aggressive-to-people rooster is to have a mixed breed rooster with lots of Dorking and Brahma in his background and let a very friendly gentle hen raise him. This seems to work better than using pure-breed roosters and us doing the raising.


It is hard to resist taking a hand in the raising though, particularly when the chicken is willing to help Katherine play World of Warcraft (Zaw, 80, Echo Isles).

The summer and fall were full of our traditional weaving & spinning demos at the Fair, helping the Ag Society to get a barn built by the Amish, and a wonderful trip to New York City. Our cooking took one of those occasional leaps forward – Tom adapted the famous no-knead bread recipe to perfection, Katherine mastered English muffins, and we realized that the Swiss style cheeses we make are some of our best. So we have started tweaking them and came up with very memorable Saffron Swiss and Caraway-Cumin Swiss (there is a Dill Swiss aging now – we have high hopes!)

And the ever present conundrum on what to take to parties and picnics in 2008 was solved by skewered stuff – we must have made 6 or 8 skewery things, sometimes with shrimp, sometimes with steak. The Solstice party was held in the middle of an impressive snow storm but Island folk are a hearty bunch and can, mostly, drive in snow so the party went on and was one of our better efforts.

2008 kept the guest bedroom filled up with friends and family – nice visits and new perspectives. Katherine turned out lots of chemo hats and in doing so finally learned to knit regular and bi-color cables (lace knitting is still unconquered territory.) Tom is weaving linen chenille hand towels on his big loom and goes curling twice a week when schedule permits. This time of year Tom is doing interviews of lower Cape and Island kids applying to Columbia.


As for 2009, in January we will celebrate out 30th anniversary! Wishing you a glorious New Year!


Category: Daily Input

Creamed Sweetbreads and Oysters

Sunday, 4 January 2009 2:02 P GMT-05
Creamed Sweetbreads and Oysters
 
2 pair sweetbreads (about 12 oz)
water
vinegar, preferably flavored (tarragon)
2 stalks celery
1/2 bunch parsley or 2 slices of parsley root
flour
ice
1 Tbsp half-hot paprika
4 Tbsp butter
1 cup heavy cream
1 pint oysters, shucked
 
Soak the sweetbreads in vinegared water for an hour, stirring once or twice. Drain. Put sweetbreads, celery, and parsley into a pot and cover with acidulated water. Bring to a boil and turn heat down to a simmer.  Simmer for about five minutes (A little more if the sweetbreads are thick) then transfer the sweetbreads to an ice water bath to cool quickly. When cold, trim and remove membranes and place in a pie pan in a single layer. put another pie pan over the top and put a two to three pound weight in the upper pan. Press the sweetbreads for about 1/2 hour. Then lay the sweetbreads on paper towels to dry.
 
Mix the paprika with half a cup of flour and dredge the dried sweetbreads to coat them.
 
Melt the butter in a skillet and saute the sweetbreads until they are a golden color. Add the heavy cream and reduce until thick.
 
As the butter is heating, cook the oysters in their liquor until they are barely beginning to curl around the edges.
 
Remove the oysters with a slotted spoon and mix with the sweetbreads. Add oyster liquor until the desired consistency is reached.
 
Season, if desired, with mace or nutmeg, and.or dry sherry. Serve over toast or rice or crepes.
 

Category: Hungry?

West Tisbury Town Party, by Dan Waters

Tuesday, 23 December 2008 1:06 P GMT-05

With the kind permission of Dan Waters, here is the poem he read on Dec 9, 2008 at the West Tisbury town party. 

West Tisbury Town Party

When beetlebungs stand bare of bough
And winter stings the air,
And woodsmoke hangs on Brandy Brow
Like wisps of thinning hair,
We waken hungry for a bite
Like some gigantic beast
And tie our kitchen aprons tight
And cook a town-wide feast.

It's quite the neighborly affair -
Warm kisses, mug to mug,
No lack of pies or news to share
With mothball-perfumed hug.
We fill our ears and stuff our face
With casserole and rumor,
And loosen belts for breathing space
To laugh at Skipper's humor.

And what's the potluck's main appeal?
Well, often it's a tossup:
Part cheap night out, part home-cooked meal,
Part good old-fashioned gossip.
We chew the fat; we laugh, complain -
It's almost like Town Meeting,
Except that here the stomach pain
Is caused by too much eating.

At last, when all's been said and chewed,
We end the night's adventure
And take a peaceful interlude
To rest both tongue and denture
Before we launch the second round
With palates hale and hearty
At Tom and Katherine's world-renowned
Hibernal Solstice Party!

© Daniel Waters

Category: Daily Input

Winter Solstice Party 2008

Thursday, 18 December 2008 8:52 A GMT-05

We are starting to seriously get ready for our annual Winter Solstice Party, Sunday, Dec 21 from noon to eight. (You are invited!)

The menu is pretty much the same as always

Whole poached salmon decorated to look vaguely like striped bass

Big ham

Chili with all the fixings

Ham and Bean Soup

Wild rice salad

Corn pudding (this is new this year)

Saurkraut and weisswurst (new last year and very popular)

People will bring desserts and finger food.

The weather is always iffy - it may be raining Sunday, the reports are still mixed about whether it will/won't rain/sleet/snow.

I'm off to go make dashi to poach the salmon in and to chop and toast the nuts for the wild rice salad.

 

Rumination 19 Waiting for Godot

Saturday, 13 December 2008 9:21 A GMT-05
Rumination 19. Waiting for Godot

By

Thomas P. Vogl

December 12, 2008


My scans three days ago showed that I was ‘stable’. That is, some tumors grew, some decreased in size or metabolic activity. The current experimental therapy that I am on (SCH727965, a Cdk inhibitor) will continue. Since I only have to go to Boston every three weeks for eight hours of infusion, and my body has become acclimated to the drug to the point where I am only uncomfortable for about 12 hours after the infusion, the current regimen exceeds my ground rule that any therapy may interfere with my life no more than 10% of my time. Getting scanned every six weeks (which takes me to Boston for an extra day – not a serious imposition) does not bother me until about two days prior, when I really want to see the radiology report now, not in three days. Unrealistic, but true. I would be remiss in failing to mention that occasional brief periods of free-floating anxiety are, not surprisingly, inevitable.


Why, then, the title of this Rumination? Because being stable is perpetually waiting for the other shoe to drop. I am also waiting to hear the results (in several weeks) of the genetic analysis of my tumor, an analysis that I give a ten percent chance of providing therapeutically relevant information. An finally, waiting for the for the breakthrough in understanding cancer as described below.


*************************************************************************************


I admit to getting older, and in six months, when I reach my 80th birthday, I will admit to actually being old; until then, I am still middle aged. You may have observed that old people like to reminisce. I have noticed in me a tendency to do likewise. Now that I do reminisce occasionally, I realize that the reason for doing so is quite different from what I had imagined it to be. I have discovered that the reason is that the perceptions of younger people about current events and their relation to historical events about which they have only read or heard about, are very different from the perceptions of those who have lived through those 'historical' events, such as WWII.


Why do I bring this up? Because scientists have the same problem in relating current events to similar historical situations, that may not be perceived as similar by those who have not lived through them. In the early 1950's, as a young scientist, I was aware of, but not personally involved in, the exciting and mystifying research coming out of the 'atom smashing' experiments being conducted on the then novel cyclotrons. Not a week would pass without another paper describing a huge variety of 'hadrons' each with a different energy. The theoreticians were busily engaged in cataloging and numerology trying to discern a pattern in these energy levels. This proliferation of particles prompted Wolfgang Pauli to remark: "Had I foreseen this, I would have gone into botany". It took eight more years until 1961, with the introduction of the quark model, that the mess of particles began to be straightened out, eventually leading to what is now called the standard model in the 1970's.


The graybeards of the time reminisced about the 1880s and 90's when, shortly after the discovery of absorption lines in the solar spectrum, emission spectroscopy produced reams of data about the spectral lines emitted by heated elements and the theoreticians all did numerology on the wavelengths and intensities of all the lines. This continued until 1900 when Max Plank proposed quantization, leading to quantum theory that offered a sound theoretical model/explanation, and all the spectroscopic lines and their interrelationships fell into place.


Despite the overwhelming similarities between the situation in the 1890's and 1950's, very few young physicists in the 1950’s believed that it would take a novel theory to resolve the problem nor that it would take close to 20 years. They had not lived, as physicists, through the 1890's.


As a graybeard, I submit that the situation in cancer research is history repeating itself. Not a week passes by that there is not at least one paper published that details half a dozen or more novel genes associated with this cancer or that disease*. Shades of the 1950's! Cataloging genes, and the associated numerology, is no more going give us fundamental insight into cancer that it did to spectral lines or hadrons. Now, as then, most active researches do not believe a new theory will be needed. I am willing to bet they are wrong; been there, done that, which is very different from reading about it in history books.


That said, I hasten to add that cataloging and numerology may produce clinically important results without necessarily shedding any light on theoretical approaches. A shining and exciting example of just this sort of fruitful analysis is a paper by K. S. Garman, et al., A Genomic Approach to Colon Cancer Risk Stratification Yields Biologic Insights Into Therapeutic Opportunity [PNAS 105: 19431-36 (December 8, 2008)]. The title does not do justice to their accomplishment. They used a Bayesian binary regression to develop a 50 gene signature that effectively distinguishes between early stage, cleanly resected, colon cancer patients with low and with high risk of disease re-occurrence. The model was successfully tested on two independent cohorts of patients (two different cohorts from the patients used to develop the model). In the process they also show that Cox-2 inhibition and PI3Kinase inhibition may well be more effective that the currently standard chemotherapy with 5-fluorouracil and oxaliplatin.


There are significant grounds for long-term optimism. I am cheered by the comment by W. D. Faulkes, in 'Inherited Susceptibility to Common Cancers’, NEJM 395:2143 (November 13, 2008) page 2150, that:




The identification of high-risk cancer susceptibility genes means that physicians and persons at risk must understand the implications of the risk

of genetic cancer; this identification has resulted in the blossoming of cancer genetics as a clinical subspecialty. Genetic counselors and other health specialists with expertise in cancer risk assessment are qualified to offer the kinds of services needed by persons with or at risk for hereditary

cancer.

Genetic testing for the highly penetrant genes listed in Table 1 is widely available (see www.genetests.org for a list of testing laboratories. Despite the apparent simplicity of the genetic tests themselves, interpretation, particularly of unclassified variants, can be much more difficult. Such complexities, including genetic sites of low impact or genetic variants of unknown significance, warrant appropriate pretest and post-test counseling for persons who undergo genetic testing. (Emphasis added by me.)


I predict that the much needed novel theoretical understanding of cancer will come out of the clinical sub-specialty of cancer genetics that studies cancer commonalities across organ systems.


****************************************************************************


* A single day’s catch from Medical Research News, 8 December 2008:

Scientists find 12 new genes with potential as drug targets
http://www.news-medical.net/?id=43866
Scientists have identified 12 new genes that are somewhat strange bedfellows: Some link gallstones and blood cholesterol levels, others link melatonin and sleep patterns to small increases in glucose levels and larger jumps in the risk of diabetes.

Discovery of 11 new gene sites that influence cholesterol or triglyceride levels
http://www.news-medical.net/?id=43882
An international research team has identified 11 novel locations in the human genome where common variations appear to influence cholesterol or triglyceride levels, bringing the total number of lipid-associated genes to 30.

Discovery of six novel genetic variants associated with lipid levels
http://www.news-medical.net/?id=43884
A new study presages a real aim of genetics: to look at whole populations to in order determine the significance of individual genetic variants for individual health.

Discovery of gene that protects against lung cancer
http://www.news-medical.net/?id=43667
A study led by researchers at The University of Nottingham has identified a gene that protects the body from lung cancer.

Curried Chickpeas and Kale

Saturday, 13 December 2008 9:21 A GMT-05
Curried Chickpeas And Kale

2 Tbsp ghee or vegetable oil
2 lg onions, chopped
6 garlic cloves, minced
2 tsp cumin seeds
1 bunch kale, deveined and chopped
1 1/2 Tbsp curry powder
1 lg knob ginger, finely chopped
2 tsp coriander, ground
2 cups dry vermouth or chicken or vegetable broth
2 cans chickpeas
1 1/2 cup tomatoes
salt

In a 2-quart saucepan, heat the ghee or oil over medium-high heat. Add the onions, garlic, cumin and ginger. Cook stirring until softened, about 5 minutes.
Add the kale; cook, stirring, until softened, about 3 minutes.
Stir in the curry powder and coriander until absorbed.
Stir in the liquid and bring to a boil. Add the chickpeas, tomatoes, and salt.
Simmer, uncovered until kale is cooked, about 20 minutes.
This recipe yields 6 servings.

Variation: Substitute Swiss chard or a 10-ounce package frozen chopped
spinach for the kale.
Comments: This is a mild curry. If you like yours spicy, stir in some ground
red pepper when you add the curry powder.

 


Category: Hungry?

3 Bears

Thursday, 4 December 2008 10:53 A GMT-05

I've been knitting little bear ornaments. Here are the first efforts.

The one on the left is very close to the original pattern .   But then I remembered all the chenille we have left from weaving and that is perfect for the bears!

 

Happy T-Day Menu

Thursday, 27 November 2008 9:57 A GMT-05

Ten of us will sit down this afternoon and feast on:

A standing rib roast with Yorkshire pudding and horseradish cream on the side

Asparagus with Hollandaise

Classic sweet potatoes with marshmallows

Roast potatoes

Biscuits

Maple glazed carrots

Corn pudding

Fruit salad that is almost a cold fruit soup (Tom thinks it is the best one I've made)

Starters are boiled shrimp with cocktail sauce, smoked bluefish and one of our cheeses and crackers

Desserts are pie and whatever shows up 

Rumination 18. Glad Tidings

Saturday, 1 November 2008 9:34 A GMT-05

Rumination 18. Glad Tidings

By

Thomas P. Vogl

November 1, 2008

 

The news is all good.  Three weeks ago I had another infusion of the Cdk-inhibitor at half the original dose and with additional fluid support. No serious side effects and it took me just four days to fully recover, for my white count to return to normal, and the tiredness to go away, nor was there any loss of smell or taste. This week we did repeat PET and CT scans that showed not only solid stability (no new spots in my liver) but an observable response to the drug in that the avidity of some of the old lesions had decreased (less dense, i.e., less metabolic activity).  Things are definitely looking up!

 

With these radiology results (which Andrew, ever thoughtful and considerate, gave me over the phone the same day!), I had the third infusion on Wednesday, again half dose and fluid support. This time the side effects were even less than before.  While still a little shaky  the evening of the infusion, by the next morning (Thursday) I felt fine – no nausea, no diarrhea, and only the slightest of headaches. By Friday morning I felt so well that both Katherine and I were amazed. I was so surprised I went over to the hospital and had them run my chemistry.  My white count was back to normal and while the anemia is still there it clearly is bothering me much less. I can only surmise that my body is getting acclimated to the drug and handling it much better.  This suggests that we could increase the dosage without any major consequences in terms of side effects.

 

Next infusion in three weeks.

 

 

It is clear that I am not the only one disgusted with the current status of clinical trials. The cover of the 10 October 2008 issue of Science features "Clinical Trials and Tribulations" and a 14 page Special Section with 5 articles bemoans the current state of affairs. Even with all that, the section does not come close to discussing the entire spectrum of clinical trial problems. None the less it is worthwhile reading.

 

Nothing like a brief upbeat Rumination, is there?

Country Mice

Tuesday, 21 October 2008 11:46 A GMT-05

Tom and I had a wonderful whirlwind visit to New York City - left Saturday and back Monday.  Even though we had the noblest of intentions to culture ourselves at MOMA and the Whitney , we ended up eating our way through the Lower East Side and Spanish Harlem, puddleducking (looking in all the windows and people watching) along the way. It was splendid!

The cab picked us up at 5:30 AM Saturday, we caught the 6:00 ferry to Woods Hole and the 7:00 bus to Boston and then the train left at 9:40 to New York at about 2:00. It was a very pleasant trip - much nicer than driving or flying. We stayed with friends, Olivia and Anna, in Spanish Harlem. They have darling apartment - much bigger than we expected for that part of the world, and were very close to subways stops. 

One thing we really wanted to do was eat outstanding Thai, and they knew just the place -  Sripraphai in Queens! It had my favorite ever dish Mo Grop (spelling?) which is a crispy pork in chili and basil (on their menu it is C18). Also incredible was item A5, crispy fried Chinese watercress salad with shrimp, squid and chicken. This is now officially my favorite restaurant and it alone is worth a trip to the city.

On the way back we stopped by Olivia's favorite pastry shop to get croissants and a little pine nut tart for breakfast. Chef Samba at Samba Bakery Cafe in East Harlem is experimenting with serving a Moroccan meal once a month or so, and it sounds so very very good!   

Sunday we headed out for a walk through China Town, admiring all the fresh produce and fish of kinds we just don't get on island. Side walk vendors were selling abalone!  Our cooking would take a whole other turn for the better if we could get these kinds of ingredients!  And, at a cooking supply place, we confirmed that no rack for a 16" wok exists, found some little dishes to match a set we are slowly filling in of the rice pattern ware, and found my little rolling pin.  (I am going to learn to make tortillas from scratch and have been asking everyone who knows of tortilla making about a palote - a short, thin rolling pin.  And everyone says to use a sawed off broom handle or sawed off [unused] toilet bowl plunger handle) Apparently Chinese dumpling makers need the same thing, and I found the perfect one. Then it was time for lunch and we met Anna's mom for dim sum at Delight 28 Restaurant (aka Hee Win Lai). We enjoyed the meal very much, and were pleased at how well our own favorite Boston dim sum place, Chau Chow City , stood up to New York.  The real treasure of the meal was Anna's mom, who is even more of a foodie than we are!

We wandered around after lunch, and officially decided we would rather wander around than go to museums.  In Little Italy we discussed cheeses with Lou Di Palo at Di Palo Selects . We stopped somewhere for gelato and ate it while watching Chinese dancers at a street fair.

 Then, for dinner (not that anyone was all that hungry but we certainly weren't going to miss the chance at another incredible meal) we went to El Paso Taqueria in Spanish Harlem. The Quesadillas de la Abuela with home made tortillas, Oaxaca cheese, chicharon, epazote, chilis, and squash blossom was super good. We also had a drink (which is popular but we'd never heard of it and I'm blocking on the name) made of dark Mexican beer, hot sauce and lime juice.

Much science and medicine and food were discussed the whole trip, I turned a heel on a sock and am ready to turn a second one, the chickens did just fine under Glenn and Rosemary's expert care, and we loved looking at all the mosaics in the subway!

A wonderful mini-vacation - and we are almost caught up with our mail, I've made a batch of English muffins for lunch, and need to do a load of laundry.

 

Rumination 17. Dear Diary

Sunday, 5 October 2008 9:37 A GMT-05

Rumination 17. Dear Diary

By

Thomas P. Vogl

October 5, 2008

 

 

Since so much has happened so fast, and despite the fact that I dislike reading (and writing) diaries, it seems that the best way to describe it is chronologically. At the end of this piece is a discussion of significant changes in cancer research that are just over the horizon and that offer hope to the next generation of cancer patients.

 

Sunday, September 28. This is the first time in two weeks that, with the help of a few Tylenol, I feel collected enough to write. There is no way around it; it has been a rough time during which I aged at least ten years and was fighting to get the decade back one year at a time. (Which I did in 10 days.)

 

It started innocently enough on Monday, September 15, with a late afternoon meeting with Dr. Geoff Shapiro and Dr. Bruno Bastos (Geoff’s charming new associate) to go over the protocol for the SCH 717965 study, sign the consent forms, and review the expected side effects, which, it was clear, are significant and unpleasant but, because of the short half-life (1.5 – 2 hours) of the drug were expected to last at most a day or two. I went into this with my eyes open and expecting nothing too awful, and it turned out worse than any of us expected.

 

Tuesday morning I had a biopsy of the malignant lymph node in my neck to provide a 'before treatment'' specimen. The rest of Tuesday and Wednesday passed uneventfully with PET and CT scans (except for being knocked down by a panel van backing into a parking space while crossing the street to spend some free time at the MFA – minimal damage done and a great show of Art Nouveau jewelry).

 

Thursday the serious part began. I arrived at the CRC (Clinical Research Center) at 7:00 am, and after some preliminary labs the eight hour infusion began around 8:00 using both lumens of my port, one for the drug and the other for a large assortment of meds including anti-diarrhea, anti-nausea, and antibiotic (the drug is known to drop white counts precipitously albeit briefly).  A scopolamine patch behind my ear (the experimental drug crosses the blood-brain barrier and is known to produce vertigo) and an IV in my arm for blood samples completed the getup.

 

Things went very well indeed most of the day with no discomfort or nausea. I had a egg salad sandwich and a fruit cup for lunch and was feeling quite chipper, although I knew that the problems would show up near or after the end of the infusion (even though the pharmacokinetics suggest that by then half of the infused drug had already cleared the system). The changes it instigated in a large number of pathways obviously are much longer lasting.

 

Near the end of the infusion (at least that’s when I think it was because I don’t remember an IV pole in the bathroom with me although I am so used to them that I may be misremembering) the diarrhea hit and with it, much to my surprise, the classic symptoms of shock – a cold sweat and light headedness.  When I came out of the bathroom my blood pressure was down to 70/40 that the prompt administration of two liters of saline (one through each lumen, running wide open) soon fixed.  I am still puzzled by the hypovolemic shock. The diarrhea was not that large a volume and I was neither bloated nor was there any obvious swelling of the extremities. Even after the two liters of saline, my urine output was still negligible. Into what compartment did all that water vanish?

This may be the right point say how impressed I have been over the past year with the astounding competence, caring, dedication, and compassion of everyone connected with the CRC – Cheryl the receptionist, the women who take your vital signs and escort you into the CRC, the entire nursing staff of whom I single out Susan Aikey only because she is my nurse and I have spent the most time with her – every last one of them are amazingly wonderful and competent people as is obvious from having watched them deal with their patients.  If every ICU in the country were staffed and run like the DFCI CRC, medical care would be of much higher quality.

 

I stayed in the CRC, in my very comfortable recliner, for another hour or so, to recuperate and get my blood pressure to stabilize. In anticipation of this kind of reaction to the drug, I had elected to stay at the Best Western motel that is immediately adjacent to DFCI and is accessible with only a few steps across a courtyard from the hospital complex. I’m glad I did because it took me more than half an hour, with rests in chairs thoughtfully provided by DFCI, for the trip of usually five minutes, picking up a container of wonton soup for my dinner on the way through the food court. I slept like a log.

 

The next morning, Friday, I went back to the CRC for blood work and vital signs and to make sure my blood pressure had returned to normal. It had. None the less, I felt tired, weak, and unsteady, rather like the morning after major surgery (except for the absence of pain). I had aged 10 years in 24 hours and was very glad to be home after five days in Boston.

 

I really expected to bounce back by Monday, but it did not happen. To add injury to insult, I noticed that my sense of taste and smell had disappeared. I could not tell whether a patty was beef or lamb! Everything else I could live with, but not that! No cliffhangers – taste did come back two weeks later.

 

Having gone through all this, I did hope that it had done me some good and the following Thursday (September 25), still very tired and shaky, I went back to Boston for a repeat PET scan. After the scan I met with Andrew who had already reviewed the scan with the radiologist. Andrew was surprised that I was not recovering faster since all my labs, except for white count, had returned to near normal, to which all I could say was “so am I”.  (The temporary abnormalities in the labs, from white count to liver function were pretty amazing – quite a drug.)The results of the PET scan were not encouraging. What we had expected to find was that the ‘avidity’ (the metabolic activity) of the metastatic hot spots had decreased significantly. But, no decrease could be found. I arrived home at 8:30 in the evening, having gotten up at 4:15 am, so tired that I just fell into bed.

 

Friday morning I awoke feeling tired and shaky as usual but mid-morning, like flipping a switch, I suddenly got back at least eight of the ten years, with only a slight headache, easily treated with Tylenol, as a reminder of what I had been through.  Today, Sunday, the headache is less but still there and the other residual symptoms are fading fast. On Thursday I will go back to Boston to meet with Dr. Shapiro and decide where we go from here.

 

Tuesday, September 30. Andrew called in the morning to give me surprising news. The drug company (Bristol-Meyers-Squib) that makes the anti-CLA4 antibody, Ipilimumab (my son-in-law, Bill Colbert, tells me that ipilimumab is a Swahili word meaning "my stomach hurts") last Thursday informed all the clinical trail centers that any patient not on the drug by the next day (last Friday) will not be allowed in a trial because of "manufacturing problems". This was the drug I was planning to go on if the Cdk-inhibitor did not work. I am reliably informed that drug companies have pulled this stunt before. My disgust knows no bounds and there is no recourse. Free enterprise, Republican version, in action. Is it not time for NIH and FDA to define, run, and publish the drug trials, combining drugs from different companies as suggested by research and patient needs (at drug company expense)?

 

Friday, October 3. Yesterday, I went up to Boston on the 6:00 am boat, as usual, to meet with Dr. Shapiro to decide what to do next. That morning's lab results showed that I was as back to normal, as I felt. We had an extended and very fruitful conversation reviewing the options now that Ipi is no longer available. There are basically two options. One is to start on one of three currently available Hsp90 inhibitors, one of which, by Schering, had demonstrated efficacy against canine mucosal melanoma. We agreed that if, note the big if, we knew that my melanoma had one of the aberrant pathways that Hsp90 modulates then it would certainly be worth trying. The reason that study is not permitted is as pathetic as it is insulting: For a biopsy tissue sample to be analyzed/sequenced, the patient must sign an IRB approved release. One of the main reasons to do the analysis is not just for the patient but for the generation of a database of cancer cell characteristics (see below). At this point which characteristics will turn out to be important are unknown. If they were known, there would be no need to do the research. But the IRB insists that a patient cannot sign a blanket release, for example, "I allow the pencil tip size piece of tissue taken from me to be used for any legitimate research purpose that does not identify me without my explicit permission" is deemed unacceptably broad by IRBs that require the specific end purpose(s) to be explicitly stated. Talk about a catch 22! Joseph Heller would be proud.

 

It also turns out that the PET scan last week that showed no decrease in avidity is a very poor predictor of the drug's efficacy. It was expected to be, but it turned out not to be; that's the nature of research. But the patient must still go through the two hour procedure anyhow, because it was written into the protocol approved by the FDA and that remains cast in concrete. The straightjackets imposed by the FDA and the IRBs are clearly counterproductive to patient safety and comfort, optimal care, and cost containment.

 

So, what we decided, since the drug certainly was having effect on me (the disappearance of my dermatitis and my hair loss both demonstrate effects on rapidly dividing cells) was to continue as we had planned for the current cycle but at half the drug dose. The next infusion will be next Thursday. Then, as originally planned, three weeks later another infusion and a repeat biopsy and definitive PET and CT scans that will give a realistic reading on whether the drug works on me or not. I am very comfortable with this plan. At half the dose, I expect to recover from the side effects far more rapidly.

 

***************************************************************************************************

 

It should not come as a surprise that I have been contemplating the state of cancer research and cancer drug research, different but interrelated subjects. I was therefore utterly delighted with the editorial in Nature (Nature 455: 138, 11 September 2008) which starts:

"Beneath cancer's daunting complexity lies a simplicity that gives grounds for hope.

"For several years now, large-scale cancer-genome studies have made it increasingly clear that a tumour cell is a genetic disaster area littered with mutations that differ not only from one type of cancer to the next, but from one patient to the next. Pharmaceutical companies have had to accept that Gleevec, a drug that treats a form of leukaemia by targeting a specific gene product, is almost certainly going to be a rare exception in the therapeutic arsenal; most cancers are far too complex to yield to such a magic bullet.

"That message was hammered home with new statistical power in three studies released last week."

The three studies focused on three different solid tumors. To make a long story short, the results are that

"The studies took a more comprehensive approach than previous large cancer-genomics studies, by simultaneously analysing genetic sequences, copy-number variations, expression arrays and other forms of data. The Johns Hopkins team looked at all the active genes in tumours from a few dozen patients; the Genome Atlas team looked at selected genes in tumours from 206 patients. Taken together, their results show that no single mutated gene lies at the heart of any of these tumours. The pancreatic tumour samples, for example, showed an average of 63 genetic mutations each — with considerable variation from one sample to the next."

Shortly thereafter, the New England Journal of Medicine (NEJM 359: 1367-1380, 25 September 2008) published a review article on the molecular origins of cancer, focusing on non-small-cell lung cancers, about 85% of all lung cancers. By comparing the rate of genetic abnormalities among the two types of non-small cell cancer (Squamous cell and Adenocarcenoma) and small cell cancer, they found that except for abnormalities in p53 which appeared in 50 – 75% of all the tumors, almost all of the other mutations occurred less than 20% of the time. These low percentages strongly suggest to me that we are not aggregating the data in the right way.

Taken together, these results lead to some obvious and far more interesting less obvious conclusions. The obvious ones, mentioned in my previous Rumination, is the demise (the sooner the better) of the block buster model of pharmaceutical research and with it, the demise of the one-drug-company-sponsored, one-drug-at-a-time clinical trial.

 

The less obvious ones deal with how the data are being analyzed, a problem that has its roots in the organization of medical education and practice, which is organized almost entirely along organ system lines. Consequently, I propose asking the question (which I have not yet seen in print but expect to momentarily): Given the poor data aggregation displayed above, does it make really sense to sort cancers primarily by organ and secondarily by cell type (as all four of these studies have done), or does it make more sense to cluster by molecular profiles? I submit, as a testable hypothesis, that the initiating processes responsible all cancers, only secondarily modulated by organ system or cell type, will be a well defined subset of mutations and epigenetic events or precursors out of the broad spectrum of genetic and epigenetic changes that have been recorded to date.

 

Put another way, cells throughout the body are more alike than they are different, particularly when it comes to the cell's internal reproductive mechanisms and controls, which are what goes awry in cancer. I therefore suggest that the research effort focus on obtaining a sufficiently large number of genetic, epigenetic, copy number, and proteonomic profiles of individual cancers of all types and from all organs so that the statistical power of cluster analysis and other statistical techniques (see the 4 September 2008 issue of Nature for a focus on "Science in the petabyte age") can be brought to bear on the question of which cancers are similar by virtue of their molecular profiles, not by virtue of the organs or cells involved. My prediction is that the number of these clusters will be far fewer than current pessimistic estimates.

 

This, in turn, leads to the currently unpalatable conclusion that clinical oncology as well as cancer research needs to be reorganized by molecular profiles rather than organ systems and that drug companies must develop mechanisms for cooperation on drug development and trials that focus on multi-drug treatment of the (soon to be identified) common constellations of molecular profiles.

 

One organization that agrees with this analysis was recently founded by my friends Dr. Jennifer Carter and June Kinoshita. They call it N-of-One. If you are interested in what they are doing and planning, their website is N-of-One.com. Because the website is still under development you will need to go to the 'REGISTER' tab in the upper right hand corner and enter a password: newvisitor – no further registration or identification is needed. [Publication of the password in this blog has been authorized by Dr. Carter.]

 

Note added in proof: I urge you to read the Commentary by Heng in the current issue of J. of the American Medical Assoc. [H. H. Q. Heng, The Conflict Between Complex Systems and Reductionism, JAMA 300:156-1581 (October 1, 2008)]. He concludes (but do read the whole article):

 

"The unpredictable nature of the [genetic and epigenetic] heterogeneity will force the consideration of the significance of clinical exceptions, because complex disease results in highly diverse responses that include many exceptions to the general rules. Furthermore, heterogeneity is not simply "noise" but a key component of evolution directly related to the human disease conditions and must also be considered when designing interventions such as cancer therapies. Clinical therapies must be individualized, balancing the parts of the system and the response of the patient as a whole. Clinical research on pharmaceutical agents needs to focus more on the differential responses within diverse patient populations."

 

The paper is two pages long and I would have included it here, but it is copyrighted, so I can only provide copies upon request to individuals, under the fair use exception. (Of course, you, the tax payer, probably paid for its writing, and undoubtedly its thinking, under an NIH grant, However, the law, in its wisdom, requires you to pay to read what you have already paid for.)

Book Reviews

Wednesday, 24 September 2008 2:46 P GMT-05

Nation is Terry Pratchett's "latest" YA novel though it doesn't take place in Discworld or any of his other worlds. Nation is set on a world more-or-less parallel to ours in something like the late 1800s. Two story lines about disasters - a tsunami in one line and a flu epidemic in another, bring two vastly different adolescents together on a deserted island. The islander boy and proper British girl have little in common except trying to survive, and then to build a nation out of what the sea washes up on the shore. This is very different from Pterry's other works (more like the Bromiliad Triology than anything else), though the footnotes he is famous for are sprinkled throughout the book.

Pratchett fans have been wondering if his early-onset-Alzheimer's has effected his writing. Judging by this book, it most certainly has not. This is one of the best books he has written lately - certainly the best for YA - and, though more could be written about this world, it is a stand-alone. It is delightful that Pratchett can write so wonderfully without all the beloved underpinnings and folklore of the Discworld. (Speaking of folklore, I've just started Folklore of the Discworld , co-written by Pratchett and Jacqueline Simpson. No opinion yet.) The book is out now in the UK and releases in the US in a couple of days.

Flora's Dare is the sequel to Flora Segunda , by Ysabeau Wilce. Tom and I loved the first Flora, and love the second just as much. You really need to read these in order, since the second book explains various of the questions Segunda left up in the air. Just wait till you meet Tiny Doom!

 

Chalice is what I've just finished reading this afternoon. It is by Newberry Medal winner Robin McKinley (The Hero and the Crown ).  I re-read Hero and the Crown and its sequel at least once a year, but haven't been grabbed by any of her other books - they were OK but not moving. Chalice changes that. It is grand! It invents its own fantasy mythology, which is refreshing, about a young woman who inherits the position of tying the land to the rulers by means of what she mixes in cup for the rituals that bind wordds to deeds to land. Also lots about bees and a word that has something to do with milk that I'm trying to track down. Anyone know what hilliehoolie might be? After I finish the blog I've go to drag down the OED and try to find it. Anyhow, a splendid book that is too short, but I hope for a sequel.

 

Magic Thief by Sarah Prineas is a more typical wizard-and-his-humble-apprentice-in-somewhere-like-London. But it is well illustrated and well written and its characters bump the boundaries of their stereotypes. It is for a younger audience than the others, but I enjoyed it.

West Tisbury Barn Raised for the Ag Society by Amish Work Crew

Saturday, 13 September 2008 4:30 P GMT-05

The crew got an earlier boat than expected last Monday and we scrambled to get lunch ready. They arrived about noon, had ham sandwiches, coleslaw, biscuits, bread and fixingings and plum cake and were on the job by 2:00.  While the women and children got organized in the houses, the men started putting up the uprights on the already prepared foundation.

The lumber had all been pre-cut and drilled, bundled and labeled by the crew in Pennsylvania so it was like watching a huge 3-D jigsaw go together.

 

This photo is after they were at work a few hours on Monday. You can see the massive framework is well underway. The beams are notched and slotted into the uprights - Tom says it is mortised &pegged, post & beam.

 

And this is what it looked like just after daylight on Tuesday morning. All the posts are up, the cross beams are being lifted up by the crane operator that works with this crew, and even some siding is on. 

 Here is one of the cross beams coming down.

 

And this is the barn by Wednesday dusk. The door was hung, windows put in, roof was shingled and all was finished by Thursday lunch (except for the side shingles that will happen in two weeks or so.) Amazing!  

The new barn fits nicely right beside the old animal barn. It is about the same size as the old one and, once the shingles have weathered, it will just blend into the landscape.

Here is a closeup of the inside of another barn built by the same crew.

Rumination 16: Bad News, Good News

Wednesday, 10 September 2008 7:32 A GMT-05

Rumination 16. Bad News, Good News

By

Thomas P. Vogl

September 10, 2008

 

I’ll dispose of the bad news first. My scans on 8/26 showed definite disease progression, particularly in the liver. Let me hasten to add that my liver function tests are still normal and my liver is not enlarged. So, I have been kicked off the trial, which is probably a good thing since it is statistically unlikely that it was doing me much good. I had very positive conversations with both Dr. Shapiro and Dr. Hodi and we agreed that there are two ongoing studies that make sense for me. One is Dr. Hodi’s  ongoing trial of our old friend MDX-010 (aka Ipilimumab) which is now available without the addition of dacabazine and is a CTLA-4 immune system enhancer. The other is a trial of a cyclin-dependent kinase inhibitor, Cdk-inhibitor, run by Dr. Shapiro, one of a new class of drugs that, at least theoretically, has a great deal of promise and has had success with melanoma in early trials. I wrote to both Dr. Shapiro and Dr. Hoi that my preference is to participate in the Cdk-inhibitor trial first, since we would find out whether it is working in six to twelve weeks whereas it will take 20 weeks or longer to see if Ipi is effective on me. It has done wonders for two friends of mine with metastatic melanoma. (I wrote most of this Rumination on 8/29 at which time I did not know which trial it will be. I must admit that the uncertainty was seriously discomforting and an e-mail from an amazing guy, Andrew Wolanski, Dr. Shapiro’s nurse practitioner and right hand man, was remarkably reassuring and calming.)

 

In the process of deciding on possible studies, I ran across a review paper on Cdk inhibitors [I. M. Chu et al, The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anti-cancer therapy, Nature Reviews, Cancer 8: 253-267 (April 2008)]. Looking at this paper reminded me why immunology and intracellular signaling pathways have always made my head spin and made me wonder whether I am sorry never to have paid much attention to those subjects or whether I am glad I didn’t.

 

{Added September 9: On September 8 I was told that I would be accepted into the Cdk inhibitor trial. SCH727965 is a novel pyrazolo[1,5-a]pyrimidine which potently and selectively inhibits the cyclin- dependent kinases CDK1, CDK2, CDK5 and CDK9. The most common treatment-emergent adverse events are nausea/vomiting, diarrhea, neutropenia, and fatigue.  However, SCH 727965 is rapidly eliminated with a terminal half-life of 1.5 to 3 hours, so that recovery from side effects is rapid. A good response has been observed in other melanoma patients in the study. I expect to start the study next week.}

 

The good news is that, at long last, someone has had the courage to announce that, as far as clinical trials of cancer drugs is concerned, the emperor is hardly wearing any clothes. M.K.B. Pamar et al, from the MRC Clinical trials Unit in London, UK, wrote ‘Speeding Up the Evaluation of New Agents in Cancer, J.N.C.I. 100: 1204-1214 ( September 3, 2008) available on-line as DOI: 10.1093/jnci/djn267. The abstract reads:

 

Despite both the increase in basic biologic knowledge and the fact that many new agents have reached various stages of development during the last 10 years, the number of new treatments that have been approved for patients has not increased as expected. We propose the multi-arm, multi-stage trial design as a way to evaluate treatments faster and more efficiently than current standard trial designs. By using intermediate outcomes and testing a number of new agents (and combinations) simultaneously, the new design requires fewer patients. Three trials using this methodology are presented.

 

Hurray for our side!

 

While I am at it, I might as well get another pet peeve off my chest. What is it about cancer that makes people talk in terms of ‘cancer survivor’ and battles and courage. We never hear of people ‘surviving’ COPD, or heart disease, or strokes, or AIDS if they live with the disease for more than a couple of years. Nor have I ever read ‘She died after a long, heroic struggle with multiple heart attacks’. Middle ear infections in children (that can lead to brain damage or death) often re-occur; when have you heard anyone say “My Johnny is a middle ear infection survivor”? Cancer is a disease like any other, sometimes fatal, sometimes not. It can re-occur. It is true that two generations ago, cancer was a mystery and its cause unknown. It was commonly undetected until symptoms appeared by which time the patient was terminal. I remember a time when even physicians would not say the word, but use ‘CA’ as a euphemism. People, its 60 years later – we know what causes cancer. Can we please stop the bullshit! I cannot say it better than Colleen Shaddox, a writer in Hamden Conn. did in the Washington Post on June 2, 2007 (page A13):

 

It's Cancer, Not a Moral Crucible

 

"You're so brave," people would say. "You're a real hero."

 

I used to get that a lot after my hair fell out. The effects of chemotherapy made me look like some plucky child protagonist in a movie of the week. Volunteering to have cancer to spare someone else the pain of it would have been heroic. But I was no volunteer.

 

"I'm not brave," I would say, "I'm just unlucky."

 

This made people uncomfortable. But I would rather do that than accept unearned praise or, worse, listen to comments that, to me, dishonor those who have died of cancer.

 

During the 10 years I've been a cancer survivor, my marriage has grown stronger, my bouncing baby has blossomed into a gorgeous virtuoso of sarcasm, and my career has taken flight. I am grateful for this life every day.

 

It's tough being a cancer patient. Surgery, chemotherapy, radiation and the prospect of painful, premature death are quite enough for one person to shoulder. The additional burden of sainthood is simply too much.

 

When strangers would observe bald little me doing something normal -- grocery shopping, for example -- they would beam like proud parents. "You are so brave!" they would exclaim.

 

Of course, grocery shopping is a necessary act, even for people with cancer, and not terribly dangerous. But my admirers persisted, as though I were suddenly extraordinary. "I could never be as brave as you!"

 

That oft-repeated line is telling. After all, if cancer is a disease for extraordinary people, the average Joe or Jane doesn't have to worry. Even in the psyches of the healthy, fear of cancer is enormous. Consciously or not, making cancer patients the saintly "other" helps make that fear manageable.

 

When I battled breast cancer, I was frequently told that God would not take a person as good and loving as I. It might be a nice thing to believe: I was a churchgoer. I'd worked in a soup kitchen, collected for Toys for Tots. I was not Mother Teresa, but then virtue doesn't make one immortal; Mother Teresa died, just like everyone else.

 

When I expressed skepticism that my character could supercharge my immune system, I was often treated to impromptu sermons about keeping a positive attitude. Consider the logic: When you have the flu, people say, "I'm sorry. Hope you feel better." When you have cancer, people expect you to maintain a positive outlook and remember that you'll come out on top. People I barely knew would quote lines such as Bernie Siegel's "There are no incurable diseases, only incurable people."

 

Ultimately, stressing the importance of positive thinking is a way of managing fear. It makes cancer controllable -- for the patients, yes, but especially for the healthy. But linking virtue, resilience and survival dishonors those who do not survive.

 

I remember watching a television segment on an athlete who'd had cancer. "Cancer really picked on the wrong person," one of those interviewed said in explaining the man's determination and ultimate recovery. So, are there right people for cancer to pick on?

 

I kept my sanity during treatment through the help of a support group. Half of these women have died. Those who did not make it had cancers with high mortality rates or cancers that were quite advanced when they were detected. The women were strong, smart and caring -- such terrific ladies that they almost made me believe the myth of cancer sainthood. But they also got parking tickets and forgot appointments, just like everybody else. They were human, and I loved them for it.

 

My friends were failed by their cells, not by their will. The horror of cancer is that it descends on irreplaceable mothers, brothers, children and friends. Some of them will die, no matter what we or they do. As we strive to honor those who had and those who are still fighting the disease, it's important to remember whom exactly our words are meant to comfort -- the people speaking, or the people in need of support.

 

********************************************************

 

I also want to recommend an exceptionally readable book, that both of us enjoyed reading, by Meredith Norton, ‘Lopsided. How having breast cancer can be really distracting. A memoir.”  Viking Press, ISBN 978-0-670-01928-1 (2008). Available from Amazon at

http://www.amazon.com/Lopsided-Having-Breast-Cancer-Distracting/dp/0670019283/ref=pd_bbs_sr_1?ie=UTF8&s=books&qid=1220102157&sr=1-1

or

http://tinyurl.com/6mx4xe

Amish Barn Raising Prep

Wednesday, 3 September 2008 7:21 P GMT-05

So the next big thing is the barn that the Ag Society is having an Amish construction group from Lancaster County, PA build. I'm helping find houses for the group to stay in and arranging food, transport and other "necessaries". It has been more than a little confusing -both on our end and on theirs about what is expected. We had thought that the work crew could stay in peoples' guest bedrooms, and that is how I first got involved when we volunteered our guest bedroom.  Then I was asked to coordinate the housing end of things and, when I talked to the head of the construction group, I found out that staying in peoples' homes was unacceptable. The group (35 or so including families) needed to be in separate houses.  That is a little difficult because a lot of the guest houses on the island are still rented out - those in the know know that Sept is a very nice time to be on island.

But I've rounded up 5 houses and have been promised another 2 or 3 (and have an apartment in reserve). The single men can't stay in a house, I gather, with women they aren't related to, so one house will be bachelor quarters. Another fairly large one will house the main family of 10 or 11, and the rest get scattered around. The idea is to find houses as close to the Ag Hall as possible, since the Amish do not drive and will have to be transported around. We are trying to find vans and van drivers to bring the workmen to the job site and the wives to the Ag Hall at least twice a day to feed the men. I won't go into details here, but if you are in a similar situation, email me and I will tell you what is and isn't working for us.

The group arrives on Monday (leaves on Saturday) and several of us involved in the non-construction end of the project are well into a quiet panic. I think housing is OK (but without a firm head count of bodies - and their ages and genders and religion [some Mennonites are coming to drive the Amish group down and operate the crane and truck down the construction supplies and those people I think need separate housing]) I'm not sure. Transportation is uncertain - even if there are enough vans, finding people who are willing to drive around up island at dawn and pick people up and deliver them to the Ag Hall is iffy (cabs have been suggested if the Ag Society is willing to pay for them). And the whole food/feeding thing is not quite settled. 

I think the group will have a light breakfast before dawn in the houses, then mid-morning the wives come with egg sandwiches. Not sure about lunch. Then in mid-afternoon the wives come with submarine sandwiches/pizza. Then dinner around 7. The Ag folks are trying to arrange with the Slow Food folks to fix a traditional New England shellfish dinner for Wednesday. And maybe hot dogs and marshmallows on the beach on Friday.  I plan to have a light lunch of ham, biscuits and coleslaw waiting when they get in on Monday and stuff for the light breakfast in the houses for Tuesday, since they won't have had time to shop and we won't have had time to transport them to the grocery store. The food thing has me worried, though one of the guest houses I found has a small but splendid commercial kitchen on the ground floor, and of course the Ag Hall has a kitchen, though it has nothing in the way of cooking pots, utensils or supplies.

 Everyone tells me it is all going to work out, but some of the details are just going to have to be worked out when the time comes. 

 

Last Day of the Fair

Sunday, 24 August 2008 5:22 A GMT-05

Sunday is the last day of the Fair. It has gone very well so far, we think in large part due to the nice weather.  We are tired but not exhausted. Have not gotten many pictures taken, but the ones below were taken by a friend who is an outstanding photographer.

Many kids were dissapointed that Tom wasn't teaching weaving, but many more (and their dads) were delighted to ask him endless questions about the loom. Tom's line this year is, "you can't wear thread, it won't keep you warm, you have to turn it into cloth."

 

Wendy's drum carder has been a huge hit. She has done wool washing and dyeing and spinning, but it is the drum carder that holds everyone's attention. Fortunately, she brought a lot to card and the rest of us had stuff that needed a pass as well. (I'm just about convinced I need a small drum carder.)

And I've been spinning and sort of re-inventing the long draw technique.

Category: Fair

Martha's Vineyard Agricultural Society Fair, First Day

Thursday, 21 August 2008 7:27 P GMT-05

Tom's daughter Wendy came down from Buffalo for the Fair. We set up yesterday, Tom's loom needed much adjustment.

We watched the oxen practicing - including a pair of calves yoked together and learning to walk around the pen, more or less.

The next day the oxen pull shows what these calves are training for.

Wendy set up a wool processing demo, going from raw wool, to washed wool, to carding to dying roving to spinning. The drum carder was the big surprise hit.

And I spun miles of black Shetland roving.

The weather is cool, breezy and clear. Perfect Fair weather and everyone is in an unusually good mood. Hope it lasts!

 

Category: Fair

Pig Flip and Hopkins Hat

Tuesday, 19 August 2008 6:33 A GMT-05

 We had a great time at the pig roast on Saturday. Here is Tom inserting the skewers of shrimp and tomatoes/hearts of palm into half of a red cabbage. We took this and skewers of tomatoes and our cheese for appetizers.

 This is the pig getting its final flip. Brian cooked it in one of the best ways we have seen. The pig was butterflied open (head removed) and the body sandwiched between two grills. The grills were bolted together and the whole thing placed over the coals. The pig cooked more evenly than the spit or buried/baked ones and had gloriously crispy skin.

 

 This is Brian and Gary deciding how to carve the pig. The pig roast brought together Brian and his friends from high school. All live (or plan to live) on the Vineyard and have kept up with each other all these years. 

 Perhaps the happiest at the pig roast were the dogs who stood under the carving table to catch the drippings!

We are going to try to sell the yarn we had spun from Anne Hopkin's sheep. It is bulky weight 3 ply, not a weaving wool and not the size yarn I usually knit with. But I knit this hat (An Unoriginal Hat by The Yarn Harlot)as a demo model and am thinking that the yarn would make a nice warm vest.

Latest bi-color cabled hat

Saturday, 16 August 2008 11:02 A GMT-05

I love this bi-color cable hat! It is a variation of the Groovy Cable Tuque I'd knit earlier in hot pink.  But it draws in so much, even with going up many needle sizes. Only aggresive block saved the hat! I think I'll save this one for me, because any time it is washed, it is going to need that same blocking.

We are headed to a pig roast this afternoon. We are taking boiled shrimp, tomatoes and cheese on picks.

Jules Immortalizes Cross, The Bursar and Me

Friday, 8 August 2008 6:41 P GMT-05

Our friend Jules Worthington has his art show opening today, an annual affair hung at the Chilmark Bank. (If you know our house, the wonderful paintings of sunsets and Italy are by Jules.) We always love going and bringing an appetizer. Today we brought skewers made of two of our goudas, Tom's pickles, ham and artichoke hearts. 

 

And when we got there, we were having a grand time wandering through the two rooms filled with paintings and really admiring a unique view of Venice and an incredible one of a fisherman in a yellow rain slicker on a boat in Menemsha. And then I walked into the next room and burst into tears. There was our rooster, Cross, and hen, The Bursar, and me feeding hens. I was so overwhelmed by it all I could only cry. They were so perfect.

 

(That is me and Karen admiring it all)

 

 me and cross

If you have met our rooster Cross, you can recognize everything about him. And The Bursar (the hen on the right named after a Pterry character) is a lovely Americana blue-egg-laying hen. The paintings hang in the Chilmark bank for a while and then move to our walls!

 

Oysters in Vinegared Bean Paste (miso)

Thursday, 7 August 2008 5:46 P GMT-05

Oysters in Vinegared Bean paste -- Kaki No Sumiso-Kake

 

20-24 oysters, shucked

2-3 Tbsp Sake

8 scallions (optional garnish)

1 Tbsp mustard paste*, Japanese

2 Tbsp miso (bean paste), white

2 tsp sugar

2 Tbsp mirin

2 Tbsp rice vinegar

 

Drain oysters, discarding liquor.

 

Combine sake with 1 cup salted water and bring to boil. Add oysters and cook just long enough to plump and begin to curl, 30 – 60 seconds. Remove oysters and drain well, reserving cooking water.

 

Blanch trimmed scallions in the bioloing water for 30 seconds, cool in cold water drain well and pat dry.

 

Mix well mustard paste, miso, mirin, and vinegar and stir until smooth.

 

Divide oysters among 4 – 6 small bowls, garnish with scallions, and pour sauce over to coat oysters. Best eaten soon after preparation but it is OK to let them marinate at room temperature an hour or two – no more – before serving.

 

*1 Tbsp dried oriental mustard mixed with a little hot water to form a paste is a good alternate.

 

Ref: Ortiz & Endo: The Complete Book of Japanese Cooking (1976), modified by KTK

Japanese food spree

Thursday, 7 August 2008 3:42 P GMT-05

We had a marvelous excuse to pull out all stops and do the best we could at a Japanese style dinner last night. We had

Appetizers of two kinds of caviar on daikon slices and green beans with ginger. Pickled oysters in a miso-mustard sauce that were fantastic (recipe coming soon), pickled shitake mushrooms, ume boshi, tofu pickled and then fried, onion salad 

 And cucumbers pickled a couple of ways and daikon.

 

Chawan Mushi - the savory egg custard we like so much with chicken, shrimp and ginko nuts

Chirashi Sushi - bite size bits of yellow tail, tuna, pickled mackerel, the funny pink powder but made from scratch from shrimp (Ebi Soboro), cooked shrimp, pickeled tofu, egg threads, semi-dried salmon over sushi rice

Ruminations 15: Lawyers 10, Science 1

Tuesday, 5 August 2008 10:44 A GMT-05

Rumination 15. Lawyers 10, Science 1

By

Thomas P. Vogl

August 4, 2008

 

The experiment that I proposed in Rumination 14, to get infused weekly instead of bi-weekly, (back issues are archived at http://upislandeggs.com/Ruminations.htm) was, as I predicted, turned down. The primary and overriding reason is that any deviation from an approved protocol must be reviewed and approved by the IRB (Institutional Review Board) of the hospital performing the study, the IRB of the drug company whose drug is being used, and the FDA. The excuse for this bureaucratic excess is that it is in place to protect the patients on the studies. I do not dispute that patients on studies (and otherwise) require and deserve protection. They also deserve to have the maximum possible information/data extracted from the experimental treatment in which they have volunteered to participate. Even more do they deserve, as long as the primary objective of the study is met, to have the option of modifying the treatment to explore the possibility of enhancing the benefit to the patient.  Ascertaining whether the experimental treatment is of benefit to the patient and, if it is not, discontinuing the treatment not because it is doing harm but simply because the patient has better things to do with his/her time (including exploring other potentially beneficial therapeutic options) is also a significant benefit, as is the scientific goal of ascertaining why the patient is doing well for reasons other than the experimental treatment.

 

I am a concrete example that may illustrate the problem. Of the 91 patients with solid tumors in the AZD-1152 trial, only two (me and a woman with lung cancer) exhibited no progression of disease – our diseases are stable. Patients with cancer occasionally exhibit stable disease without treatment. The standard explanation is that their immune systems are responding appropriately to the disease.  Consequently, there is a very real question whether AZD-1152 is actually effective in a few percent of the population because of the specifics of the genetics of our tumor or whether the drug is ineffective in solid tumors given the dose limitations imposed by side effects.  This is not an academic question.  If a trial drug is working, the patients should certainly stay on it. If their stability is unrelated to the drug, then it would be far better for them to try a different regimen, sooner rather than later when their natural defenses which are keeping the disease stable start to crumble.  The patients, of course, have no basis for making such a decision and their oncologists are prevented by the bureaucratic red tape from ever finding out.  In my case, the experiment I proposed was both simple and safe: Give the infusion every week instead of every other week and check the white cell count twice as often. If it starts to drop significantly, discontinue the experiment.  Since my count dropped only once, after the first infusion, and then only slightly, the risk in my case is minimal, not zero, but minimal. Other patient’s white counts have/will react differently but individual differences are not taken into account in the early trials, which, in my opinion, is one of the principal reasons so many expensive Stage III trials fail.

 

It is only since I have become personally involved that I have realized how absurd the IRB system has become since its initiation for patient protection. A large part of the problem is the amazing reliance that has developed  on the legal fiction of ‘informed consent’; the paper work for which consume the IRBs (and whose primary function is to protect the pharmaceutical industry, hospitals, and doctors from lawsuits). The reality is that the typical patient, even the very well educated and informed one, does not have either the background or the technical knowledge to perform the scientific evaluation that is required to give *informed* consent, that is, knowledgably concur that the experiment to be performed on him/her can reasonably be expected to bestow a perceived benefit that overrides the risks. Only the lawyers who wrote the rules for the IRBs can persuade themselves that giving informed consent and signing an informed consent form are in any way a comparable activities or indicative of the same mind set. The correspondence is pure fiction. The reality is that the patient is told about possible benefits and adverse effects orally and then told to take the form home and read it or, if you prefer and want to get started - a delay may jeopardize your slot in the study - just sign here.

 

In the July 18, 2008, issue of Science, page 324, is an amazing example of the absurd damage to science and scientific progress that the current IRB implementation has brought on. It is reported that a respected team of scientists at the University of Tokyo have been forced to retract a paper because “it apparently failed to obtain informed consent from tissue donors or from their IRB. Observers believe the problem stems in part from guidelines that do not sufficiently explain how to handle samples collected before Japan established informed consent procedures.”  Now I am not suggesting that IRB rules and regulations should not have teeth. However, retraction is a totally inappropriate remedy for any cause other than scientific error or fraud. As it stands, readers of the journal will know only that the paper has been retracted and will assume that it contains erroneous data or misleading conclusions, when that is not the case. This cuts the heart out of what the archival record means in science and illustrates the potential for, and the reality of, abuse of power inherent in IRBs. It punishes the scientific community, not the ‘perpetrators’.

 

On a different note, I was reliably informed that the experiment of treating weekly instead of bi-weekly had been performed in Holland (the home country of the developer of the drug) and that they found that some fraction (I have no idea what fraction) of the patients developed leucopenia on the weekly treatment, which is why they opted for the bi-weekly protocol.  That may well be true, but is that a good reason not to try it on a patient (me) who had only the mildest leucopenia in response to the first treatment and never thereafter? Particularly, since the weekly trial could be stopped at any time? Further, the weekly infusion was not on patients with stable disease. Yet further, in that the same dose was given to all patients irrespective of their weight.  Still further, since the trial has officially been terminated and only the few patients who are stable are, by courtesy, continuing to receive the drug – but of course only under the conditions imposed by the original protocol, now discontinued because it did not work. And beyond all that, that rarity, the proposed experiment is on a patient, me, who can give meaningful informed consent. The lawyers win, patients and science loses, and all asses are covered. Sic transit gloria mundi.

 

I want to state quite clearly that I do not blame any individual physicians or teaching hospitals for this state of affairs. None of them wanted this absurd system foisted upon them. However, some blame does accrue to them collectively. If they, collectively, announced that unless the system was appropriately modified they will conduct no further clinical trials, the system would be changed within months. But who will volunteer to take the responsibility for herding cats?

 

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I was recently asked on what evidence I based my decision to take celecoxib (Celebrex, a COX-2 inhibitor) and the omega-3 fatty acids (fish and flax oil). Since this is a very reasonable question, I thought it appropriate to replicate my answer in these Ruminations. The COX-2 / omega-3 story is complicated since they interact in their biochemistry via the prostaglandin pathways. My choice was also based on my genetics.

Let me begin with the science by providing a bibliography of some of the more relevant papers. I have copies of most of them if anyone is interested enough to read them. Otherwise, the titles will suffice to suggest the basis of my decision:

A. Bundschere et al., Antiproliferative and proapoptotic effects of rapamycin and celecoxib in malignant melanoma lines. Oncology Reports 19: 547 - 553 (2008)

C. Lee et al., Expression of cyclooxygenase-2 and peroxisome  proliferator-activated receptor gamma during malignant melanoma progression. J. Cutaneous Path. (2008) doi:10.1111/j.1600-0560.2007.00939.x

S. K. Lee.
et al., Vitamic C suppresses proliferation of the human melanoma cell SK-MEL-2 through inhibition of COX-2 expression and the modulation of insulin-like growth factor II (IGF-II) production. Cell. Physiol. 216: 180 - 188 (2008)

 Kast, R.E., Melanoma inhibition by cyclooxygenase inhibitors: role of interleukin-6 suppression, a putative mechanism of action, and clinical implications. Med. Oncol. 24: 1-6 (2007)

K. Muller-Decker et al., The cyclooxygenase-2 mediated prostaglandin  signaling is causally related to epithelial carcinogenesis. Mol. Carcinog. 46: 705-710 (2007)

 J-C Marshall et al., The effects of a cyclooxygenase-2 (COX-2) expression and inhibition on human uveal melanoma cell proliferation and macrophage nitric oxide production. J. Carcinog.
6: 17 doi:10.1186/1477-3163-6-17 (2007)

J. C. Marshall et al., The use of a cyclooxygenase inhibitor (Nepafenac) in an ocular and metastatic animal model of uveal melanoma. Carcinogenesis 28: 2053 - 2058 (2007)

F.J. Lejeune et al., Complete and long-lasting regression of disseminated multiple skin melanoma metastases under treatment with cyclooxygenase inhibitor. Melanoma Res. 16: 263-265 (2006)

K. S. Wilson, Cyclooxygenase-2 inhibition and regression of metastatic melanoma. Melanoma Res. 18(?): 465-466 (2006)

K. S. Wilson, et al., Clinical activity of Celecoxib in metastatic melanoma. Cancer Invest. 24: 740 -746 (2006)

S. Xia et al., Melanoma growth is reduced in fat-1 transgenic mice: Impact of omega-6/omega-3 essential fatty acids. PNAS 103: 12499-12504 (2006)

 Y. Denkins et al., Role of w-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. J. Lipid Res. 46: 1278 - 1284 (2005)

C. Denkert et al., Expression of cyclooxygenase-2 in human malignant melanoma. Cancer Res. 61: 303 - 308 (2001)


The COX-2/ Omega-3 story is particularly relevant in my particular case for two reasons that, until I thought about it, I had previously always thought were unrelated.

I have had a life-long affliction from hereditary polymorphic light eruptions (PMLE). My mother had a mild case, I have a severe case, and one of my daughters has an intermediate case.  In the past, if I spent 15 minutes in the sun, three days later I would break out in typical PMLEs.  Several very competent dermatologists have tried to help over the years, including a course of PUVA (psoralen & UV light), but nothing helped. Until I started taking omega-3 supplements. With the usual dose, the PMLEs decreased significantly in severity and on the double dose I am now taking they have disappeared completely.

I also have hereditary colonic polyps (not polyposis).  Both my parents died of colon cancer. I had my first polyp removed at age 40 and few harvested every couple of years since, until I started taking 200 mg/day of Celebrex about 7 years ago. Since then, not a single polyp in three scopings.  If 200 mg/day will completely suppress the colonic precancerous lesions, might my melanoma also have similar pathways, given my genotype? 400 mg/day is the clinically accepted maximum dose so why not see if that will help, given that I have no cardiovascular risk factors. (The Celebrex also does a great job keeping my lumbago/sciatica under control.)

That is why I concluded that it would be prudent to increase my intake of both omega-3 fatty acids and COX-2 inhibitor. Neither can do me significant harm. Given my genetics, I think that they are likely to do me some good by reducing tumerogenesis.  That is why I proposed the experiment to Dr. Shapiro to increase the frequency of AZD-1152 for one cycle to see if it makes a difference. It may well be, given that AZD-1152 at the accepted tolerable dose has not been a success in over 90% of solid tumor patients, that my stability derives from the omega-3 / Celebrex in collaboration with my immune system and not the AZD-1152.  It would be nice to find out, but given the rules under which the IRBs and FDA have chosen/been forced to operate, it will not happen. So, I really have no meaningful choice but to stay on the current regimen and travel to Boston every other week for two days for infusion, even though that effort may have no bearing on my well being and it would be so easy to find out whether or not it does.  Alas, we will probably never know.

 

There is a glimmer of light at the end of the tunnel. Current commentary by scientists and clinicians express the growing realization that anti-cancer monotherapy block-buster drugs are illusive if not illusions. Whether this will cause the pharmaceutical companies to explore and collaborate on novel multi-drug therapies or abandon the development of anti-cancer drugs remains to be seen.